| (11) | Registration Number: | P20202058 (Validated european patent) | |
| (21) | File number: | P20202058T |
| (22) | Date of filing the request: | 23.12.2020 |
| (45) | Patent Publication Date and Gazette Number: | 19.02.2021 |
| (54) | English Title: | PYRAZOLO[1,5-A]PYRIMIDINES USEFUL AS INHIBITORS OF ATR KINASE FOR THE TREATMENT OF CANCER DISEASES |
| (96) | Number of the European patent application: | EP 18159811.1, 06.12.2013 | |
| (97) | Publication data of the European patent application: | EP 3418281, 26.12.2018, 201852, en | |
| (97) | Publication data of the European patent: | EP 3418281, 30.09.2020, 202040, en | |
| (51) | IPC: | C07D 487/04 (2006.01) |
| | | C07D 453/02 (2006.01) |
| | | C07D 471/08 (2006.01) |
| | | C07D 487/08 (2006.01) |
| | | C07D 491/107 (2006.01) |
| | | C07D 498/04 (2006.01) |
| | | C07D 498/10 (2006.01) |
| | | A61K 31/495 (2006.01) |
| | | A61P 35/00 (2006.01) |
| (73) | Holder(s): | | 1. | Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, MA 02210, US |
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| (72) | Inventor(s): | | 1. | Nadia Ahmad, 86-88 Jubilee Avenue, Milton Park, OX14 4RW Abingdon Oxfordshire, GB |
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| | | 2. | Dean Boyall, 86-88 Jubilee Avenue, Milton Park, OX14 4RW Abingdon Oxfordshire, GB |
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| | | 3. | Jean-Damien Charrier, 86-88 Jubilee Avenue, Milton Park, OX14 4RW Abingdon Oxfordshire, GB |
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| | | 4. | Chris Davis, 86-88 Jubilee Avenue, Milton Park, OX14 4RW Abingdon Oxfordshire, GB |
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| | | 5. | Rebecca Davis, 86-88 Jubilee Avenue, Milton Park, OX14 4RW Abingdon Oxfordshire, GB |
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| | | 6. | Steven Durrant, 86-88 Jubilee Avenue, Milton Park, OX14 4RW Abingdon Oxfordshire, GB |
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| | | 7. | Gorka Etxebarria I Jardi, 86-88 Jubilee Avenue, Milton Park, OX14 4RW Abingdon Oxfordshire, GB |
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| | | 8. | Damien Fraysse, 86-88 Jubilee Avenue, Milton Park, OX14 4RW Abingdon Oxfordshire, GB |
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| | | 9. | Juan-Miguel Jimenez, 86-88 Jubilee Avenue, Milton Park, OX14 4RW Abingdon Oxfordshire, GB |
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| | | 10. | David Kay, 86-88 Jubilee Avenue, Milton Park, OX14 4RW Abingdon Oxfordshire, GB |
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| | | 11. | Ronald Knegtel, 86-88 Jubilee Avenue, Milton Park, OX14 4RW Abingdon Oxfordshire, GB |
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| | | 12. | Donald Middleton, 86-88 Jubilee Avenue, Milton Park, OX14 4RW Abingdon Oxfordshire, GB |
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| | | 13. | Michael Odonnell, 86-88 Jubilee Avenue, Milton Park, OX14 4RW Abingdon Oxfordshire, GB |
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| | | 14. | Maninder Panesar, 86-88 Jubilee Avenue, Milton Park, OX14 4RW Abingdon Oxfordshire, GB |
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| | | 15. | Francoise Pierard, 86-88 Jubilee Avenue, Milton Park, OX14 4RW Abingdon Oxfordshire, GB |
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| | | 16. | Joanne Pinder, 86-88 Jubilee Avenue, Milton Park, OX14 4RW Abingdon Oxfordshire, GB |
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| | | 17. | David Shaw, 86-88 Jubilee Avenue, Milton Park, OX14 4RW Abingdon Oxfordshire, GB |
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| | | 18. | Pierre-Henri Storck, 86-88 Jubilee Avenue Milton Park, OX14 4RW Abingdon Oxfordshire, GB |
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| | | 19. | John Studley, 86-88 Jubilee Avenue, Milton Park, OX14 4RW Abingdon Oxfordshire, GB |
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| | | 20. | Heather Twin, 86-88 Jubilee Avenue, Milton Park, OX14 4RW Abingdon Oxfordshire, GB |
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| (74) | Representative: | PETOŠEVIĆ d.o.o.,
Ulica Josipa Račića 2, 10000 Zagreb, HR
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| (30) | Priority Data: | | (31) | 201361868132 P | | (32) | 21.08.2013 | | (33) | US | | | 201361787568 P | | | 15.03.2013 | | | US | | | 201261734726 P | | | 07.12.2012 | | | US |
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| (62) | Original Application Number and Date | EP13811716.3; 06.12.2013 | |
| (46) | Publication Date of Translation of a European Patent Claims and the Gazette Number: | 19.02.2021 |
| | Annual fee: | 20.11.2025 for the 13th year | |
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